Age and year ranges and countries uploaded.

Age and year ranges and the number of countries uploaded should correspond to the numbers expected given in Table 1.

Expected number of rows

The expected 'number of rows' in this table is 51005, (age classes x years x countries). If the number expected is different from the uploaded, please compare Table 1 against Table 3, and take a look at Fig. 1, 2 and 3 for some insight.

In Fig.3, we are comparing the observations expected for this model (blue line) against what has been uploaded by the modeller (orange area/dots). The missing/excess observations correspond to the area between the blue and orange lines. The figure aims to represent the birth cohort being followed over time, so that in a dynamic model we are expecting a rectangular shape whereas for a static model a 'trapezoidal' shape is the minimum expected. Some static models can also have a rectangular shape.

In Fig. 4 we are checking the patterns of zero values in the upload.

Zero values are normal in many cases, and we expect either absence, minimum presence or a random pattern of them. When a non-random pattern of zero values is observed, this plot can help in interpreting some of the intentional assumptions or systematic errors that cannot be seen in Fig. 3 (i.e. absence of estimates of an outcome in some age classes or in a whole birth cohort).

Comparison of cohort size against interpolated population in all countries

Comparison of cohort size against interpolated population in PINE countries

Fig. 7 and 8 show absolute and relative difference respectively, between interpolated population and cohort size by country for this model.

Age patterns

Here, we look at the aggregated (for all countries) age distribution patterns by outcome.

Global burden values by decades 2000-2030

Figure 10 shows the total estimates of burden by decades between 2000-2030 (for the total number of countries) to see if the estimates are reasonable for the different scenarios.

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Total burden values

Table 7 shows the total burden from all countries and age groups for no vaccination and vaccination scenarios. These values should correspond to the total across all ages from Fig. 11.

FVPs 2000-2100 (PINE countries)

Table 8 shows the total fvps for each scenario in the PINE countries for the same period as shown in Fig. 12. These values should correspond to the total across all years from Fig. 12.

Disease burden values (PINE countries)

Table 9 shows total burden estimates for all years and ages for each scenario from PINE (Pak-Pakistan, IND-India, NGA-Nigeria and ETH-Ethiopia) countries.The values should correspond to the total values from Fig. 13 for each scenario and burden outcome.